AMD Simulator: Advanced Age-Related Macular Degeneration Tool

Base color

Model & settings

AMD type

AMD severity100%

Perceptual severity curve Multi-pass deep Metamorphopsia warp overlay

Image simulation

Choose image Upload JPG/PNG (max 1200×1200). Simulated canvas next to original.

Research notes

AMD simulation models three clinically distinct progression stages: dry AMD with drusen (early-intermediate haze and contrast loss), geographic atrophy (late dry AMD with central absolute scotoma), and wet neovascular AMD (choroidal neovascularization causing metamorphopsia and rapid central scotoma). Peripheral vision is preserved across all stages.

Swatches — Reference vs AMD

Reference

HEX: — • RGB: — • xy: —

Simulated

HEX: — • RGB: — • xy: —

ΔE (CIE76)

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ΔE (CIEDE2000)

—

Deep preview

Reference

Simulated

Chromaticity (CIE xy)

AMD drusen scatter axis (toward D65)

D65 white point: 0.313, 0.329

Image simulation

Multi-condition comparison

Condition A

Condition B

Steps

Compare normal, Condition A and Condition B across multiple severities. If an image is loaded it will be processed into the grid, otherwise color swatches are shown.

Advanced mode

Severity curve

Curve param

Cone weights (L,M,S)

Clinical notes: M-cone weight set to 0.95 and S-cone to 0.85 to model differential photoreceptor vulnerability in AMD — S-cones (short-wave/blue-sensitive) and M-cones are preferentially affected in early AMD due to RPE dysfunction in the S-cone rich parafovea and macular pigment loss. These settings approximate cone sensitivity changes; they are simplified and intended for research/preview only — see model assumptions for limits.

Model assumptions & limits

This model operates in sRGB; it approximates cone weighting by scaling channel contributions.
Severity curves are heuristic (linear/sigmoid/gamma) and do not replace clinical diagnoses.
ΔE and chromaticity measures use standard CIE conversions but depend on display/profile.