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Simulate aniridia visual effects from absent or severely hypoplastic iris diaphragm — including profound photophobia, veiling luminance glare, foveal hypoplasia acuity loss, and nystagmus blur across partial aniridia, complete aniridia, and comorbid glaucoma stages. Inspect ΔE & chromatic shifts from iris aperture loss and scatter across the full pupil.

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Base color
Aniridia stage & settings
Severity100%
Image simulation
Upload JPG/PNG (max 1200×1200). Simulated canvas next to original.
Research notes
Aniridia is a bilateral congenital condition caused by PAX6 haploinsufficiency, where the iris is absent or severely hypoplastic, eliminating the pupillary diaphragm. Without an iris aperture, light floods the retina uncontrolled → profound photophobia, nystagmus, and acuity reduced by foveal hypoplasia. Progressive complications: aniridic keratopathy, cataracts, and secondary glaucoma. The photophobia checkbox adds sigmoid veiling luminance from uncontrolled off-axis light.
Swatches — Reference vs Aniridia
Reference
HEX: — • RGB: — • xy: —
Aniridia
HEX: — • RGB: — • xy: —
ΔE (CIE76)
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ΔE (CIEDE2000)
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Deep preview
Reference
Simulated
Chromaticity (CIE xy)
Photophobia scatter axis (to D65 white)
D65 white point: 0.313, 0.329
Image simulation

Simulations operate in linear sRGB. Partial aniridia applies graduated veiling luminance proportional to remaining iris hypoplasia; complete aniridia overlays full radial glare and contrast reduction from uncontrolled off-axis pupil flooding; comorbid mode adds lens scatter (Gaussian σ ∝ severity) and peripheral contrast loss from elevated IOP. Photophobia checkbox applies sigmoid veiling luminance. ΔE2000 measures perceptual shift toward white from glare.

Multi-condition comparison
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Compare normal, Condition A and Condition B across multiple severities. If an image is loaded it will be processed into the grid, otherwise colour swatches are shown.