Base color

Disease stage & settings

Disease stage

Inflammation severity100%

Perceptual severity curve Multi-pass deep Photophobia (veiling luminance)

Image simulation

Choose image Upload JPG/PNG (max 1200×1200). Simulated canvas next to original.

Research notes

Sympathetic ophthalmia is a rare bilateral granulomatous panuveitis following a penetrating injury or surgery to one (exciting) eye, triggering an autoimmune response to sequestered uveal/retinal antigens in the fellow (sympathising) eye. Dalen-Fuchs nodules (epithelioid cell aggregates between RPE and Bruch's membrane) cause patchy choroidal scatter and distortion; anterior chamber granulomatous KPs contribute photophobia; vitreous haze reduces contrast. The simulator models choroidal granuloma scatter, vitreous haze and photophobia across three stages. Not diagnostic.

Swatches — Reference vs Sympathetic Ophthalmia

Reference

HEX: — • RGB: — • xy: —

Simulated

HEX: — • RGB: — • xy: —

ΔE (CIE76)

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ΔE (CIEDE2000)

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Deep preview

Reference

Simulated

Chromaticity (CIE xy)

Uveal scatter axis (choroidal granuloma)

D65 white point: 0.313, 0.329

Image simulation

Simulations operate in linear sRGB. Early stage applies mild choroidal scatter from nascent Dalen-Fuchs nodules; active inflammation overlays granulomatous aqueous scatter with vitreous haze from panuveitis; chronic recurrent mode adds longer-term photoreceptor desaturation from RPE disruption. Photophobia checkbox adds sigmoid veiling luminance from ciliary nerve sensitisation. ΔE2000 measures perceptual colour shift from uveal granuloma scatter and veiling luminance.

Multi-condition comparison

Condition A

Condition B

Steps

Compare normal, Condition A and Condition B across multiple severities. If an image is loaded it will be processed into the grid, otherwise colour swatches are shown.

Advanced mode

Severity curve

Curve param

Scatter weights (R,G,B)

Clinical notes: Uveal granuloma scatter is predominantly achromatic Mie scatter from epithelioid cell aggregates and lymphocytes. A mild blue bias (w_S=1.1) reflects the scleral/uveal Rayleigh component from protein exudate in the anterior chamber. The chronic recurrent mode includes a modest RPE disruption desaturation component from progressive cumulative retinal pigment epithelium involvement. Not validated against clinical photometry.

Model assumptions & limits

Choroidal scatter from Dalen-Fuchs nodules applied globally; real nodules are focal/patchy between RPE and Bruch's membrane.
Photophobia modelled as veiling luminance; actual sympathetic ophthalmia photophobia is from anterior chamber inflammation and ciliary spasm.
RPE disruption in chronic mode is approximated by desaturation; true RPE changes cause focal scotomas and metamorphopsia not captured here.