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Simulate Fuchs endothelial corneal dystrophy across progressive corneal haze, morning edema and advanced guttae scatter modes. Tune disease stage severity and inspect ΔE & chromatic shift caused by guttae-driven endothelial failure and stromal oedema.

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Base color
Progression stage & settings
Disease severity100%
Image simulation
Upload JPG/PNG (max 1200×1200). Simulated canvas next to original.
Research notes
Fuchs endothelial dystrophy results from progressive endothelial cell loss and guttae (extracellular matrix excrescences) on Descemet membrane, causing endothelial pump failure and corneal oedema. Corneal haze mode applies diffuse Gaussian scatter; Morning edema mode models diurnal worsening; Advanced scatter simulates guttae-mediated micro-aberrations. Severity maps to endothelial cell density (ECD) and corneal central thickness (CCT).
Swatches — Reference vs Fuchs Endothelial Dystrophy
Reference
HEX: — • RGB: — • xy: —
Simulated
HEX: — • RGB: — • xy: —
ΔE (CIE76)
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ΔE (CIEDE2000)
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Deep preview
Reference
Simulated
Chromaticity (CIE xy)
Scatter axis (toward D65 white)
D65 white point: 0.313, 0.329
Image simulation

Simulations operate in linear sRGB for optical accuracy. Corneal haze mode applies Gaussian diffusion scatter; morning edema mode adds diurnal severity bias; advanced scatter simulates guttae micro-aberrations. ΔE2000 measures perceptual colour shift from scatter-induced whitening. Use severity to blend from clear cornea (0%) to severe Fuchs decompensation (100%).

Multi-condition comparison
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Compare normal, Condition A and Condition B across multiple severities. If an image is loaded it will be processed into the grid, otherwise colour swatches are shown.